The work of Berridge and Kringelbach informs us that there are several hedonic hotspots in the brain, such as the hotspots in insula, orbitofrontal cortex, nucleus accumbens, ventral pallidum and in nucleus parabrachialis. We know that even the complete lesions of the most well-known hedonic structure, the medial shell of the nucleus accumbens, may not have to reduce or prevent sensory pleasure. Even in congenital decorticed children with hydranencephaly, who are well-treated, real hedonic responses occur.
Is it possible that the hierarchically lowest hedonic structure of the brain is pontine nucleus parabrachialis?
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