Hi,
I have prepared my niosomes using HEPES buffer and test their stability at 4,25,37 and 50C.
I have found they are stable now for about one month at all the tempretures except the 4C where the size and the PDI increase dramaticly.
does that make since to be unstable in the fridge? does anyone came across that or have any explaination?
thanks
Dear Mohammad Ali,
I suggest that you read the paper of Sharma et al. entitled "SPAN-60 NIOSOMAL ORAL SUSPENSION OF FLUCONAZOLE: FORMULATION AND IN VITRO EVALUATION " which studied the stability of niosomes at low temperatures and found them to be stable (see Figure 5 and conclusions section).
To view the full publication, please use the following link:
file:///C:/Users/Rafik%20Karaman/Downloads/63-120-1-SM.pdf
Hoping this will be helpful,
Rafik
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