Purple rashes, swollen legs, clogged catheters and sudden death — all are signs of blood clots, large and small, that are a frequent complication of COVID-19, and researchers are just beginning to untangle why. It’s not just the presence of blood clots that has scientists puzzled: it’s how they show up. “There are so many things about the presentations that are a little bit unusual,” says vascular biologist James O’Donnell.

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