My purpose is to map hotspots using LISA tools (or in general local statistics). By developing GIS application using available spatial statistic libraries (i.e. PySAL - ESDA), I have still not found documented methods (or suitable literature) to include in the computation more than two variables.

Have you any suggestions on how to map simultaneously hotspot or significant spatial clusters of more than two variables?

In the following link one of the papers (Anselin et al. 2002) I have considered as reference

http://europa.nvc.cs.vt.edu/~ctlu/Project/SoftwareTools/multi_lisa.pdf

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