I am currently working on the development of a mucoadhesive microemulsion spray designed for use within the oral cavity. The formulation aims to incorporate both water-soluble natural compounds (such as thymol) and an oil-soluble antibiotic. However, I am facing a few challenges and would appreciate your expertise.

  • Formulation Guidance: Could you suggest a suitable formulation for a mucoadhesive microemulsion spray that also functions as an in situ forming gel in the oral cavity? The compounds in question have limited stability, so stability considerations will be crucial. Additionally, all components should be biocompatible.Key requirements:Water-soluble natural compound (e.g., Epigallocatechin Gallate (EGCG) Oil-soluble antibiotic e.g Clindamycin In situ gelling ability Biocompatible excipients Avoidance of heat or harsh processing methods due to stability concerns
  • Proving In Situ Gel Formation: What would be the best approach to prove and characterize the in situ gelling ability of this formulation once administered into the oral cavity? I am looking for reliable in vitro or in vivo methods to demonstrate the transition from liquid spray to gel and ensure sufficient mucoadhesion and sustained release properties.
  • I look forward to your suggestions and insights on optimizing this formulation. Thank you in advance for your time and expertise.

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