I want to do Aza - Michael Addition of Bis amines (NH2-R-NH2) and acrylate compound (CH2=CH-R). I only need 1 acrylate group react with 1 primary amine to form R-NH-CH2-CH2-R.
Is there any method to prevent second addition of Acrylate Compound to Primary Amines?
Thank you so much.
Ashis Ranjan Bandyopadhyay
Use large excess of the amine compared to the acrylate, so that the probability of the acrylate species to find a fresh amine is relatively enhanced. Work with a lower conversion level.
You may try the following.
0 votes
0 thanks
Maksim Fomin
Hello Loc, the answer to your question is quite well explained in the paper (Ganachaud et al, Progress in Polymer Science (2017), 72, 61-110) in attachment.
0 votes
0 thanks
Joscha Breibeck
Hi Loc,
you could also think about protecting one amine moiety within you starting material to ensure only one reactive site per molecule.
0 votes
0 thanks
- Badges
- Science topic
- Similar topics
- Heat
More Loc Nguyen's questions See All
Similar questions and discussions