I seek multiple feedback and discussion which can disprove my idea that:
Activation of MHb (by mu-opioids, nicotine, acetylcholine, ATP and glutamate) and disinhibition of MHb by endocannabinoids activates the IPN which activates MRN that activates via serotonin (or Glu) the claustrum.
Claustrum is known to cause slow-wave oscillations (SWA) in cortex, during slow wave sleep (SWS). I proposed that also during anesthesia.
So the activation of this circuit causes loss of awareness in SWS and anesthesia and many anesthetics activate this circuit.
MRN serotonin also inhibits theta states, recording of new hippocampally bound memories, wakefulness and REM by inhibiting theta and arousal and REM linked regions.
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