Definately, because pesticides are organochlorines & organophosphates and these thus these gets accumulated within the adipose tissues and thus can blocks lipid metabolism.
The naturaly pesticides are interfere in the adipose tissue blocking the metabolism
The naturaly pesticides are interfere in the adipose tissue blocking the metabolism. What naturaly pesticides do you refere? seems interesting.
LM
organo chlorine (OC) and organo phosphorous (OP) pesticides are lipophilic and have high affinity towards lipids that I agree. But the adipose tissue is not the only one with lipids, of course it is the place where our excess fats are deposited. There is a very important organ which is rich in lipid ie., the brain. Moreover all the cell membranes are made of phospholipids.
The mode of action of pesticides varies with the type of pesticides. Both OC and OP are mainly neurotoxic, of wich OP compounds pose a serious health hazards in animals and humans.
The cytoplasmic nerve endings of the synaptic membrane contains acetycholine (Ach) which is the neurotransmitter and is present in special vesicles. Ach is sythesised by the enzyme Ach Esterase from Acetyl CoA and Choline. The Ach contents are released into cholinergic receptor protein molecule of the postsynaptic membrane and changes in its configuration enabling Na & K cations to penetrate. Thus transferring of the nerve impulses takes place. This process is very brief & is followed by the hydrolysis of Ach by choline esterase (ChE). The organo phosphorous (OP) pesticides acts against this hydrolysis. They produce phosphorelation of the esteric binding side of ChE and stop the hydrlolysis of Ach. Which leads to the accumulation of Ach and subsequent neurotoxic symptoms.
In the case of DDT, it cause significant chnges in brain-lipid metabolism. Studies have shown that DDT cause significant decline in the levels of total lipid, unesterified cholesterol & phospholipids in brain. At the same time it elevates spingomyelin production also. The lipids associated with the myelin sheath are more resistant to pesticide injury while cholesterol and phospholipids metabolisms become affected which eventually leads to the impairment of central nervous function of the animals.
Hope this answers your question.
Motor Neuron Disease a recently heard disease, is it due to pesticide accumulation effect?
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology