I'm trying to perform polymorph screening of one of dihydropyridines, at current moment I'm in a search of solvent-antisolvent combination for it.
Maybe the following papers are helpful to you,
Best
B.J. Ridder, A. Majumder, Z.K. Nagy, Parametric, Optimization-Based Study on the Feasibility of a Multisegment Antisolvent Crystallizer for in Situ Fines Removal and Matching of Target Size Distribution, Industrial & Engineering Chemistry Research, 55 (2016) 2371-2380.
R. Baratti, S. Tronci, J.A. Romagnoli, A generalized stochastic modelling approach for crystal size distribution in antisolvent crystallization operations, AIChE Journal, 63 (2017) 551-559.
You could make some solubility tests: choose a solvent in wich it is well solubilized, while the antisolvent has to be something in which it is quite bed solubilized.... and add a volume of antisolvent 3 or 4 time the volume of solvent!
Best regards
Emanuele
https://sites.google.com/site/miller00828/in/solvent-polarity-table - this is valuable guide to explore. Extremal limits are perfluorinated carboranes (in human life timescale) - and liquid inert gases (like Xe) or perfluorinated compounds (e.g. SF6 or perfluoroalkanes) from other side
(CF3)2CHOH is most polar solvent from non-ionizing compounds (>10% above water); perfluorohexane is most available from less polar compounds.
Thank you for your answers. I tried to use halogenoalkanes with hexane as antisolvent, some of mixtures gave me the crystals. Mixtures of methanol with some solvents which i chose as antisolvents didn't gave me result, but i mixed them with proportion 1:1, next time i'll try to use 3-4 parts of antisolvent or reverse addition.
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