Is 10 ns good enough to analyze the results for MD Simulations for drug discovery?

I am running MD simulations for 10 ns only and I was wondering if this is good enough to analyze prospective drug candidates for 6M71.

22 October 2020 5,955 16 View

Why does adding Urea to a medium (mixture of different salts) decrease its conductivity?

I have 2 ponds. The only difference between these 2 is that one has Nitrate and the other has UREA. I observed that each time i feed the pond with urea, the conductivity decreases. What can be the...

02 May 2019 4,960 4 View

How can I improve the attachment of electrospun polymer nanofibers mat with the collector sheet?

I am using Aluminium (Al) sheet as the collector sheet but the polymer nanofiber mat is very poorly attached with the Al sheet, I just want to improve the attachment.

19 December 2018 7,939 2 View

How to decide from where you want to start translation of your protein in an expression vector?

I am workig on Non LTR Retrotransposon and I want to find out from where should I insert my sequence? Just a breif background- The component I am working on is R9 which targets 28S rRNA . I need...

29 June 2018 6,330 3 View

I am having problem with cloning a 2.2 kb fragment into pCMV Tag 2B vector using BamHI and EcoRI restriction sites. Any suggestions?

I want to clone a 2.2kb fragment in pCMV Tag 2B vector using BamHI and EcoRI. I usually do a PCR(My PCR gives 3 faint non specific bands above my desired product size). So I run a gel and then...

08 August 2016 4,285 8 View

Hi can u plz suggest me sum gud topics related to disease that is more prevalent these days

I want to do ph.d on the topic related to a disease that is prevalent now-a-days. can u plz suggest me sum gud topics that can help me.. thanks

05 September 2011 5,714 1 View

Fatty acids and their testing

What is the best way to solubilise palmitic and oleic acid respectively ?

01 January 1970 2,120 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

Are there methods for automatically mapping floodplains, fans and terraces?

I want to map these river geoforms with as little subjectivity as possible. I have a high resolution DEM generated by drone data.

22 February 2021 7,800 3 View

How to use Remote sensing and GIS applications for mapping the available medicinal plants within the locality/municipality?

Hello, I'm very interested in mapping and managing the conservation of the Philippine traditional medicinal plants, in which I think is very helpful in the field of medicine for further analysis...

21 February 2021 374 5 View

What are the limits of determining metastability in the brain?

What are temporal limits in determining brain metastability? In other words, how long does the minimum length of the scan segment using fMRI have to be for the result to be of any value? I'm...

07 February 2021 2,380 2 View

Are the hyperspectral image datasets which are publicly available at ehu.eus website atmospherically and geometrically correct?

I've come across a couple of publicly available hyperspectral image datasets from the website http://www.ehu.eus/ccwintco/index.php/Hyperspectral_Remote_Sensing_Scenes Now, my concern is...

05 February 2021 3,550 1 View

I'm trying to do pixel-wise correlation comparison of two datasets? Any available procedure or codes to perform this?

I'm trying to do pixel-wise correlation comparison of two datasets? Any standard procedure or codes to perform this? Like Correlation Coefficient map and RMSE map of a particular region.

31 January 2021 2,959 8 View

How to extract peak coordinates from a given cluster with MATLAB as in the SPM results viewer?

Hello everyone, I am trying to extract peak coordinates from given clusters in an 3D fMRI group image, e.g. a thresholded ICA z-score map. Using MATLAB/SPM I am able to extract a single peak...

26 January 2021 7,672 2 View

Does the pre-synaptic neuron location in a cortical map influences the spatial position of its synapses in the dendrite of the downstream neuron?

Are functional maps in the cortex used by the brain to carry out computations or are they just a byproduct of wiring minimization? A key element to answer this question is to know if, when...

26 January 2021 1,118 8 View

How to fix the voids on a floodplain map by using HEC_RAS model?

24 January 2021 9,054 2 View

How can I solve this problem in my "Direction flow" map?

Hi I am working on a study and need to create "Flow line" by a tool in ArcGIS same as "Direction flow". You can give the topographic map to this tool and it can return you the flow direction map...

18 January 2021 1,728 8 View