An interesting aspect is the mis-match between the pharma approach to improving cognition (a worthy goal, nevertheless) and the caregiver's need to keep the patient at home. (Cognition is perhaps less of an issue there than the incontinence, midnight wandering, sundowning etc, that comes with advancing AD). Can pharma embrace a more holistic approach to the patient, and think creatively about other goals that might meet the patient and caregiver goals, other than improved cognition?
Although this article, below, was written in 2013, it still has practical ideas related to this important question. You might be familiar with it, but I want to alert other participant to this particular article.
"Cognitive enhancers: what they are, how they work and what is in the pipeline"
https://www.pharmaceutical-journal.com/news-and-analysis/cognitive-enhancers-what-they-are-how-they-work-and-what-is-in-the-pipeline/11117394.article?firstPass=false
See also (2017) Safety, effectiveness of cognitive enhancers for Alzheimer's ranked. (and the reference) Article Comparative Effectiveness and Safety of Cognitive Enhancers ...
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