Discussions , questions and issues about the application of Quantitive Pharmacology in discovery/ preclinical are wellcome at PK/PD group (https://www.researchgate.net/group/PK_PD/)
Kind regards
Stefano
Hi, I observed a strange behaviour in my cell lines I had never seen before. Those are stable lines from Ovarian cancer (line's name: HEY) and from Prostate cancer (line's name: PC-3). Both lines...
08 April 2024 1,418 0 View
Dear friends, I am Stefano Cipriani and dong an ecolabel that will be useful for the market, especially to increase use of recycled materials. I have a question that would love to share here in...
27 March 2024 5,298 3 View
Consider two clocks set just under the surface of water, they are synchronized. One of them departs at velocity v and then rejoins at -v. The overall time dilation must be the same as the one in...
14 March 2024 2,203 86 View
I recently discovered that BFA is used in flow cytometry, enabling the observation of intracellular cytokines that would be otherwise released. Is the same principle applicable to ROS? I would...
04 March 2024 7,094 1 View
Does an ip E.coli injection (10^8 ) cause death in 4 hours in C57BL/6? Do I need to hydrate the mouse? Is this a good concentration to mimic a septic situation?
04 March 2024 4,552 1 View
I'm searching for a comprehensive textbook or paper on power-split and compound architectures in hybrid electric vehicles (HEVs). I've come across some very interesting papers on HEVs. However,...
11 February 2024 8,516 0 View
Good day, may you suggest a reference method for micrometers calibration? Thanks in advance Stefano
06 February 2024 8,027 3 View
Hi ResearchGate community, can anyone help us out with this contamination? We work with iPSC-NPC. This contamination happens ONLY when we put the neuronal progenitors in coverslips + media for...
14 December 2023 6,435 0 View
Dear all, do you know what is the correct subsample size (number of pixel) to carry out a confusion matrix? I am digitizing the true classes on an image to check the accuracy of the classifier....
11 August 2023 6,528 2 View
Hy, may you suggest a method to determine citrate and citric acid by ionic cromatography? Thanks in advance Stefano
08 June 2023 1,441 0 View
I have extracted essential oil from a medicinal plant and want to make several concentrations for some biological activities (Antidiabetic assay). How can i prepare the several concentrations to...
04 July 2024 8,100 4 View
I have nearly completed my preparation for the short communication. However, I could use some assistance with the results. Any help would be greatly appreciated.
12 June 2024 4,230 1 View
Understanding and Managing Constipation: A Comprehensive Rev... Can you explain the treatment options for adult constipation, including both non-pharmacological and pharmacological approaches?
24 May 2024 8,259 3 View
What pharmacological agents are used in the treatment of DI, and how do they work?Advances in Understanding and Management of Antidiuretic Hor...
08 May 2024 8,585 1 View
Are there any specific considerations for the dosing and administration of dexmedetomidine in patients with renal or hepatic impairment?Dexmedetomidine: A Comprehensive Review of Pharmacology,...
08 May 2024 1,747 1 View
Can you explain the pharmacological mechanism of action of dexmedetomidine and how it differs from other sedativesDexmedetomidine: A Comprehensive Review of Pharmacology, Cli...
08 May 2024 2,755 2 View
. What are the FDA-approved indications for dexmedetomidine, and how have its off-label uses expanded over time?Dexmedetomidine: A Comprehensive Review of Pharmacology, Cli...
08 May 2024 9,245 1 View
I would like to understand the calculation of % enzyme inhibition
28 April 2024 4,359 1 View
Methods are based on Chel-Guerrero and colleagues'Phytochemical Profile, Toxicity, and Pharmacological Potenti... . We use a 1M Tris buffer with pH of 6.8, with Bovine Serum Albumin as the...
25 April 2024 8,802 0 View
Understanding Pain Physiology: Foundations for Effective Chr... Multidisciplinary pain management approaches involve the collaboration of various healthcare professionals from different...
19 April 2024 6,268 1 View