Paleo diet method is one of the successful diet method for diabetic, obesity, HT. The main concept of this food method is simple as avoid glucose completely. And there is no restriction for the natural lipid and protein intake.
"Following the Paleo diet can lead to an inadequate calcium intake.[2]
The digestive abilities of modern humans are different from those of Paleolithic humans, undermining the diet's core premise.[8] Although little is known about the diet of Paleolithic humans, it is very likely that they consumed wild grains and legumes. During the 2.6 million year long Paleolithic era, the highly variable climate and worldwide spread of human population meant that humans were, by necessity, nutritionally adaptable; in contrast, supporters of the diet assume that human digestion has remained essentially unchanged over time.[9] [10][11]"
As usual this diet method also having some drawbacks. But as I said early this diet method is very useful to control diebetic, obesity and hypertension. But there is no much information about impact on other diseases. Regarding this diet method a long term assessment is required. Because this food method suggests that meat should be the primary food and few ancient books suggests that consuming meat as a major food is a wrong habit. But those books are not describing the actual effects of meat on human. Regarding this detailed research is required because still we don't have complete knowledge in nutrient impacts on human physiology and health.
btw, there are different kinds of meat and a potential impact of consuming mostly meat is known (ketosis state could go as far as ketoacidosis - https://en.wikipedia.org/wiki/Ketosis#Ketoacidosis, https://en.wikipedia.org/wiki/Ketoacidosis)
Ketone bodies are known to cause kidney damages. Ketoacidosis condition was observed in many heavy meat consumers. But in such reports, there is no much information about the patient physical activity, the amount meat intake, patient hunger status, number of times meat taken, etc (unknown). When we take limited amount, I think there is no problem. Ex. Eskimos community. They only consume sea food (non-veg). But their community is healthier one.
There is one more issue about lipid rich meat. Lipids are not healthy to the (hepatic) jaundice patient.
I doubt if avoiding glucose is the main point. Paleolithic people consumed minimal galactose, no trans fats, no artificial sweeteners, preservatives, colourings or flavourings, probably limited fructose most of the year, probably limited omega six fatty acids, and probably limited lectins. In most places they probably ate lots of vegetables and fish or shellfish. I do not advocate a paleo diet, but one that incorporates the above points. I do suggest non-paleo foods, like split lentils without skins, sourdough bread, hard cheese not milk, and vegetables more than fruit.
Currently, paleo consumer main target to reduce glucose intake. So they have to avoid most of the packed food items which contains either glucose and saturated fat. Most of the scientists agree that meat has less carbohydrate but it is rich source for protein, lipids and other micro nutrients. So if we follow the paleo diet strictly, we need one or two additional food items to get some nutrients mostly vit C. But if we follow we need to vary food in day to day life. The people who don't have idea about food and nutritipn they might face some problem. Such people need to have an advisor (Dietician).
I don't think the main target should be reduction of glucose. A paleo diet should minimise lectins, which are in the bran layer of seeds, and so in wholemeal bread, wholegrain pasta and whole pulses. Lectins bind to specific sugars in the body, causing problems. It should avoid concentrated fructose in cakes, biscuits, sweets, puddings, high fructose corn syrup, soft drinks and fruit juice. There should be no milk, thus avoiding galactose, which damages arteries. There should be no artificial additives, and artificial trans fats. A paleo diet can contain plenty of vegetables, fish, meat, and a little fruit, seeds and nuts. The vegetables provide vitamin C.