I have a set of SNPs which shows allele specific differential TF-binding affinity (ref>alt allele, as considered). Now I want to know whether the TFs obtained have positive or negative regulatory effects on a particular gene through in silico approach?
Some transcription factors are thought to be dedicated stimulators or repressors, aside from these, I do know now of a way to use sequence alone to predict. Perhaps whole-transcriptome expression studies exist in a public repository in which the TF of interest was either up or down regulated? This might yield a clue, just a clue, as to its function.
Thank you @Seth Crosby. Could you plz tell me how to predict transcriptional activators and repressors from sequence info? Any tool for this? I am new to this field.
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