How can we calculate the sample size for rodents for a particular period of time?

How can we calculate the sample size for rodents for a study for one year? Are there any specific protocols to be followed for designing rodent sampling? How long should be the sampling interval...

01 March 2021 1,056 3 View

Can someone help me with tissue histology of mice?

I've been trying to assess the efficacy of a drug that I've purified in mouse model. I've induced mammary tumors in balb/c mice and treated them with my drug. I've harvested the tumors, and other...

16 December 2020 3,515 3 View

Can anyone help to get this research paper on OCB?

Turnipseed, D & Murkison, G (2000). Good Soldiers and Their Syndrome: Organizational Citizenship Behavior and the Work Environment, North American Journal of Psychology 2(2)

11 November 2020 7,488 3 View

What are some landmark texts and papers on agroecology we need to follow for a clear understanding?

We often read a lot about sustainable agriculture or conservation agriculture (or recently, climate-smart agriculture) but it is often difficult (especially for early-stage researchers) to fathom...

08 April 2020 9,212 10 View

Can anyone share me a better image of the attached map? In which book the map was originally published?

The map is reproduced in Eaton, Richard M. The Rise of Islam and the Bengal Frontier, 1204-1760. Berkeley: University of California Press 1993; reference given are: Barrie M. Morrison,...

13 August 2019 1,485 2 View

Does 4T-1 cells induce ascites in mice?

I am new to in vivo research. I have tried to induce solid tumors in mice by injecting 4T-1 cells in the mammary fat pad, which is an established procedure. While i mostly ot solid tumors, 2 or 3...

18 June 2019 973 3 View

How to solve problems arising from choosebank() command in R?

I am using seqinr package in R. But when I am giving the command choosebank() to find out the existing databases or commands like choosebank('swissport") to open any specific database, R is...

15 April 2019 1,541 3 View

What is the scope of Fortran in machine learning?

I intend to use ML for molecular dynamics simulations and want to know of packages available in Fortran. Would it be more efficient to use some other language instead for the long run?

09 January 2019 8,295 2 View

Which regression/multivariate technique to apply if dependent var is continuous scale, cant be categorised, non-normal, Indep Variables dichotomous?

02 September 2018 1,981 2 View

For droplet-based sc-RNA sequecing data, library size varies across cells. How does one tackle this when calculating statistical variance for genes ?

To calculate the statistical quantities like variance or mean expression of a gene across cells, it is unfair to compare expression counts of a say gene A, if we know different cells has not be...

14 July 2018 10,016 2 View

Guidelines for survey (question type) analysis?

Hi. Please tell me what guidelines should i need to follow for questionaries' type research work in India. It is not hospital based work, we are conduction basic institutional based qualitative...

03 March 2021 2,037 3 View

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02 March 2021 932 1 View

What is the best surface to culture cells isolated from a skin biopsy?

Hello, recently I am having some difficulties with maintaining the cell culture of primary cells isolated from a skin biopsy (normal and malignant). The coating of culture plates with Matrigel (a...

26 February 2021 6,151 2 View

Is it efficient to do liquid biopsy to investigate the gene expressions of the tumor?

To do liquid biopsy and look for specific gene expressions there are so many published papers. Thera are different protocols and procedures used to isolate circulating cell free RNA or mRNA from...

23 February 2021 7,326 5 View

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19 February 2021 8,647 3 View

May I know how to determine the acceptable intakes for new types of nitrosamine discovered in drug?

Currently only common nitrosaminse like NDMA and NDEA have mentioned the acceptable daily intake. Based on EMA guidance, should refer to ICH M7 chapter 7.5 guideline. I have read but could not...

20 January 2021 522 1 View

The First Survey Addressing Patients with BMIs over 50?

Dear Bariatric Surgeons, The importance of obesity management in patients with BMIs over 50 has not been completely addressed and it should be considered separately from patients with morbid...

20 January 2021 2,748 1 View

Can fibrosing cholestatic hepatitis in an immunocompromised patient be diagnosed without a liver biopsy?

provided that all the criteria for diagnosis has been fulfilled and alternative diagnosis are also ruled out. The patient has coagulopathy and transjugular biopsy wont be possible due to resource...

13 January 2021 8,935 4 View

Is it necessary to validate the control test for each FFP separately?

Hi everyone, I would like to ask if it is necessary to validate the control test (eg sub-visible particles) for each Finished Pharmaceutical Product (FPP) separately (using the same method, the...

06 January 2021 5,568 3 View

What are the primary defects associated with welding druring construction-stages which might influence the capacity of the gusset-plate connections??

Dear researchers What are the primary defects associated with welding druring construction-stages which might influence the capacity of the gusset-plate connections in concentrated braced frames?...

06 January 2021 797 3 View