I found many diverse views taking about the calculation of calcium ionized depend on Albumin level and total calcium
they are so different and can not trust any
Why do you want to estimate ionized Ca? Don't you have access to a more accurate ionspecific electrode for Ca?
Ionized calcium in serum is not only dependend on total calcium and albumin, but also on pH, globulin content and anions like phosphate / citrate. Disease state may effect the reliability of the estimation by for example the Payne equation.
Some publication that deal with this matter are:
- https://www.aacc.org/cln/articles/2019/june/ionized-versus-albumin-adjusted-total-calcium
- https://acutecaretesting.org/en/articles/ionized-calcium
- https://academic.oup.com/ndt/article/15/11/1841/1918601
You might consider trying this newer method of estimating iCa, which adjusts total calcium for albumin and the 3 components of the anion gap:
https://qxmd.com/calculate/calculator_704/predicting-hypocalcemia-in-critical-care
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