If we can develop plant proteins to that extent where we can use them as a bio similar.it would be great. i would like to know the information related to these..i searched , but didn't got any information on this...almost everything is possible in science..I hope so...
I think its possible to produce biosimilar proteins in plant.
Here are few references which may be useful.
http://www.ncbi.nlm.nih.gov/pubmed/18634133
http://www.ncbi.nlm.nih.gov/pubmed/7766897.
thanks rahul...researchers should concentrate in this.....im looking for a platform to take up this subject...i have some findings too...
Plant proteins are proteins that are produced by plants or derived from plant sources. Plant proteins can be used to create biosimilars of monoclonal antibodies and other therapeutic proteins that are used to treat various diseases, such as cancer, HIV/AIDS, Ebola, etc.
There is some research going on plant proteins that are similar to biosimilars. For example, scientists have created plant biosimilars of trastuzumab and pertuzumab, which are antibodies that target the human epidermal growth factor receptor 2 (HER2) in breast cancer cells (1). They have also modified the Asn297-linked glycan of the antibodies produced in a plant with fucosyltransferase and xylosyltransferase gene knockouts to improve their biological activity.
Another example is PlantForm, a Canadian biotech company that has turned to tobacco plants to create monoclonal antibodies and proteins to treat cancer, HIV/AIDS, Ebola, and other diseases. They have three biosimilar candidates for Herceptin (trastuzumab), Avastin (bevacizumab), and Humira (adalimumab) (2).
(1) The biological activity of bispecific trastuzumab/pertuzumab plant .... https://www.nature.com/articles/s41598-019-52507-9.
(2) “Growing” Biosimilars How Plants Bolster Manufacturing Efficiency. https://www.biosimilardevelopment.com/doc/growing-biosimilars-how-plants-bolster-manufacturing-efficiency-0001.
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