Likely to be individual response to plaques and tangles in the brain, such as immune system and inflammatory response. We simply don't know what causes AD at the moment.

There most likely are many causes of AD.

One prominent theory is loss of autophagy. This dysfunction

allows deposition of tau protein. Rapamycin inhibition of the

mTOR pathway allows improvement in autophagy and repair

of damaged proteins etc.and suggests therapeutic effects.

Mitochondrial dysfunction is also involved. The loss of normal

cell function due to severe mitochondrial damage from various insults

ie ischemia, toxins, hyperglycemia, direct physical damage etc.

Cells die at an advance rate via apoptosis.

I love this topic....so much to learn

Lester Mandelker DVM

Fellow AAVPT