Is there any prediction tool for predicting protective antigens and pathogenic antigens?

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Muralidhar Katti

Antigens will have two components, one eliciting antibody (and immune) response and bind with them, and two virulence, contribute in pathogenesis. Thus in vaccination virulence component of the antigen is attenuated to retain its capacity to produce immune response. In other words, virulent antigen(s) on attenuation can be protective.

Harish Chandra

Dear Muralidhar,

Thanks for your response Do you know any software tool which can predict virulence nature of a protein and protective component!

It depends on pathogens you are looking for. Since genomic sequence of most of pathogens are available, you will have to fish out sequence of antigen of your interest and then analyze.