I need this reagent but it's not possible to get this air to my place.
I found that to synthesize N-butyllithium, I need Lithium.
Anyone has alternative ways to synthesize N-butyllithium without involving Lithium?
Thank you very much.
The bond Li-C is the most labile among another bonds Li-X and so it is not likely to built it. If You try to react any Li compound (LiH for example) with any active reagent (BuX) You will obtain LiX and butane. ONLY if the reacnion will have no another choice it will go to Li-C bond creation. So if we have Li-Li (or may be Li-Na? bonds) this compons may be useful in obtaining BuLi. All Lithium sats are unuseful. We have at first obtain Li as metall (by electrilisys) and then involve it in reaction with BuCl to obtain BuLi
Thanks a lot.
By the way, is there any other alternative chemical that can be used instead of N-butyllithium?
In what reaction? there are a lot of metal-organic compounds. In some cases it can be Gringard reagents (RMgX), in some cases another metals. But as a rule lithium organic compounds is the MOST active (Na- organic compounds of course are more active but VERY unstable) so in such reaction as LITHIATION of benezene (ArH to ArLi) all other metal-organic compouns are not effective
Thanks Petko,
I would like to alkylate the fluorene.
Please kindly look through the attachment.
Is it possible to replace the N-butyllithium with others?
Many thanks. ^^
You should be able to alkylate fluorene in DMSO or under phase-transfer catalysis conditions using simple bases like solid NaOH.
Hi, Birman. Thanks for the suggestion.
I am a newbie for this synthesis. Could I have some reference methodologies regarding these two synthesis pathways?
Many thanks.
It is easier to buy BuLi than to buy lithium and prepare the BuLi yourself.
Phase transfer is a good and cheap option.
http://www.phasetransfer.com/03tip11.htm
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