I am trying a sonogashira reaction of an aryl chloride with trimethyl silyl acetylene compound. I found that it requires different conditions than classic sonogashira reaction. For example, 1) CuI have inhibitory effect, 2) an inorganic base rather than amine base should be used. 3) Xphos ligands are used.
Hence, I need a method for this coupling without using XPhos ligands.
Chen Jingwen
First of all，you should know that a sonogashira reaction of an aryl chloride is more difflcult than reaction of an iodobenzene，so the reaction may need XPhos ligands in most cases. Second, I have read an articles about sonogashira reaction without any ligands and copper catalysts, which may inspire you (J.Org.Chem. 2006, 71, 2535-2537.).
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