I am trying a sonogashira reaction of an aryl chloride with trimethyl silyl acetylene compound. I found that it requires different conditions than classic sonogashira reaction. For example, 1) CuI have inhibitory effect, 2) an inorganic base rather than amine base should be used. 3) Xphos ligands are used.
Hence, I need a method for this coupling without using XPhos ligands.