The last update of haploidization and its future perspectives was written by Drs Jan Tesarik and Carmen Mendoza in 2002 (Somatic cell haploidization: an update, Reproductive BioMedicine Online, 2002, 6(1):60–65) . Is there any new update or report of live births from this approach?
Dear Islam,
I assume that this problem is very far from realization. I cite here Aponte et al. who reviewed them:
Haploidization is a modified cloning technique, in which each parent genetically contributes with a haploid complement, but unfortunately this technique offers no immediate perspective for clinical application.
Although extensive research has been and continues to be performed, biotechnologies described on this review article still remain largely experimental.
Aponte PM1, Schlatt S, Franca LR. Biotechnological approaches to the treatment of aspermatogenic men. Clinics (Sao Paulo). 2013;68 Suppl 1:157-67.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583150/pdf/cln-68-s1-157.pdf
Sincerely Pavel Travnik
I would like to share my new work presented at COGI22
https://www.researchgate.net/publication/282150098_Blastocysts_derivation_after_somatic_cell_fusion_with_premature_oocytes?ev=prf_pub
I am now writing the paper.
Best regards,
Islam
Conference Paper Blastocysts derivation after somatic cell fusion with premat...
We (my husband, Professor Neal First) and I had a student that studied haploidization in the bovine model. She did manage to get development to the morula stage but not beyond that. I will add that a few embryos did look as though they were "trying" to develop into blastocysts but they were far from normal. With a little work I can dig out her thesis if there is interest.
Thank you Dr Marijo for your answer, it would be fine if you share the results of your student's thesis. I am sharing my new findings published last month
https://www.researchgate.net/publication/293645245_Blastocysts_derivation_from_somatic_cell_fusion_with_premature_oocytes_prematuration_somatic_cell_fusion
Article Blastocysts derivation from somatic cell fusion with prematu...
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