These high-resolution techniques will never outdate molecular simulation as the latter can provide details that are not experimentally accessible. But they can be of great help in evaluating simulation techniques and their underlying models. It is still not sufficiently appreciated by the modelers that their results can only be trusted if the validity of their methods and models is critically tested by experiment. High-resolution optical techniques allow testing on a finer level than before.
These high-resolution techniques will never outdate molecular simulation as the latter can provide details that are not experimentally accessible. But they can be of great help in evaluating simulation techniques and their underlying models. It is still not sufficiently appreciated by the modelers that their results can only be trusted if the validity of their methods and models is critically tested by experiment. High-resolution optical techniques allow testing on a finer level than before.