1. you can use non-centrally active ACE inhibitor like quinapril. Even so, there are some articles that say it can penetrate blood/brain barrier in high dosages.

http://cardiovascres.oxfordjournals.org/content/34/3/575

2. other option can be guanethidine, that does not cross blood/brain barrier.

https://profiles.nlm.nih.gov/ps/access/XFBBGD.pdf 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482245/pdf/bripharmchem00065-0080.pdf

There are some experimental methods to show the centrally mediated effects of an antihypertensive drug. First, if an intravenous administration of the drug lowered blood pressure and induced a bradycardia instead of a reflex tachycardia, you can suspect a central effect of the drug. Second, you can inject the drug directly into the central nervous system (into the cerebral ventricles, into the vertebral artery, into the cisterna magna or microinjection into the nucleus tractus solitarius or medullary raphe nucleus, etc.) at doses not effective by the peripheral route (generally a 1/10 of the peripheral dose). If these low doses lowered blood pressure, the drug may have a centrally mediated effect. You can also test the drug in pithed rats or after pre-treatment with hexamonium (a ganglionic blocker). Under these conditions, a hypotensive dose of the drug may not induce reduction of blood pressure, even if the blood pressure is enhanced by perfusion of angiotensin II or by vasopressin. As you suggest, you can also compare the effects of your drug with a known centrally acting one. Hope this may help.

Dear Darciuc and Dabire, thank you for your concern and suggestions.

Best wishes

I didn't not concern on hypertensive drug. Right now in Thailand, we are applying alternative innovation of myself namely SKTs Meditation healing exercise as a tool and will be a national policy for 10 yrs among 9000 hospitals in Thailand  to control high blood pressure and some NCDs. Anyway  you can test or compare side effect of hypertensive drugs and this methods what it can involve BBB or not. Cheers. 

Most dihydropyridines Ca modulators have no access to the brain at least for therapeutic dosages.

The ACEI benazepril, enalapril, moexipril, and quinapril do not cross BBB (centrally inactive); The ARBs Eprosartan, Irbesartan,Losartan, Olmesartan, Valsartan do not cross BBB but data are contradictory (Losartan both cross , and does not cross)