Gynecomastia is a known side effect of antidepressants. Is it universal for them or there are some exceptions?
It seems that gynecomastia is a common side effect. If it is very disturbing liposuction is an alternative.
It is belived that gynecomastia is associated with altered dopamine neurotransmission and perturbations in sexual hormones. These adverse effects MAY be medication induced. Selective serotonin reuptake inhibitors (sertraline), serotonin-norepinephrine reuptake inhibitors (duloxetine), have been reported to cause these adverse effects. May be you can check other SSRIs or a partial dopamine D2 receptor agonist antipsychotic aripiprazole for depression treatment.
The prevalence of gynecomastia with different groups of antidepressants is difficult to ascertain, as the literature is predominantly case reports. However, one small prospective study noted this adverse event in 39% of woman receiving antidepressant therapy (paroxetine 64%, fluoxetine 25%, sertraline 25%, and venlafaxine 11%). I couldn't find any case report on bupropion induced gynecomastia. Another option in mild-moderate depression is agomelatine, though a single reported case of gynecomastia in 2013.
Wellbutrin (bupropion) causes infrequently gynecomastia
Dear all,
I beg to differ with you all vehemently.
Since 10 years I have not yet observed gynecomastia among my patients who are receiving antidepressants.
Please be aware, all side effects mentioned in literature are not clinically significant and their occurrence may not be significant.
Gynecomastia is not a common side effect.
My teacher in medical college used to say, rarely you are correct when you think of rare things and commonly you are correct when you think of common things.
In man, have been reported a gynecomastia case after sertraline. As the sertraline total daily dose was reduced, gynecomastia symptom severity rapidly decreased. Within 4 weeks of the last sertraline dose, the patient reported resolution of gynecomastia. Sertraline and duloxetine have been reported to induce gynecomastia, with duloxetine reported to induce hypogonadism with gynecomastia. The pathophysiology of gynecomastia for SSRIs and SNRIs is altered dopamine neurotransmission, with hyperprolactinemia or perturbations in sexual hormones.
Gynecomastia is a rare side effect any antidepressants.
Most clinicians and patients need not focus on it's possibility.
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