Biotech product formulations challenges?

For end product (prefilled syringes, vial, etc.) is necessary to take in consideration the formulation of the matrix of the API, let's say recombinant protein before the end product formulation...

31 December 2017 7,349 2 View

How do you develop a formulation to a biosimilar?

What if the suplier excipients don't match my formulation?I mean they make their own "solution" or liophilized product. Do I just ignore this and make my own formulation or do I need to base my...

31 December 2016 3,807 5 View

What's the best way to encapsulate lyzozyme in liposomes from sodium lauril sulfacetate?

I need a fast way to do it, and I've been looking at some protocols where people use other components.. And also they use an ultrasonicator (which my lab doesn't have..) So I looked up a...

01 February 2014 8,646 1 View

Can someone advice on whether a protoplast culture can produce secondary metabolites? And what's the difference in their cell culture?

I want to know the difference between the production of secondary metabolites in a cell-suspension culture and in a protoplast culture

06 July 2013 6,947 1 View

Which is the most convenient manufacturing software for Additive Manufacturing?

Which tools can be used to generate machine codes for additive manufacturing?

02 March 2021 7,220 2 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

Is anyone familiar with the cyclic compressive fatigue testing (BS EN 12697 - 25) ?

I would like to get more information on the cyclic compressive fatigue testing (BS EN 12697 - 25) which is typically done for bituminous material in pavement design. Any one can advise on the...

28 February 2021 2,004 3 View

Stress/strain tensors decomposition ???

25 February 2021 6,760 1 View

What software programs can directly simulate Additive Manufacturing Directed Energy Deposition (DED)?

I understand there are a lot of software programs that can simulate DED by going through specific modeling, simulation, and commands. For me, that was time consuming and results were not accurate....

24 February 2021 4,428 3 View

How to formulate Energy minimization in Molecular dynamics simulation for alloys using meam potential?

during MD simulation, the atoms are not moving as per required. The problem (as per my observation) lies in energy minimization technique. upon application of tensile strain in x or y direction,...

22 February 2021 380 5 View

The most suitable method to calculate the stress intensity factor in the presence of contact between the crack lips?

I'm trying to study cracked structures under a compressive load taking into account contact between the crack lips. I would like to know if the method of extrapolation by displacement remains...

21 February 2021 8,694 4 View

How to differentiate the economic productivity in agriculture and in manufacturing sector?

Most of the references I found were on the economic productivity in agriculture but very limited application in manufacturing sector. I would appreciate if anyone could share the references on...

15 February 2021 8,342 7 View

What is the optimal method to prepare a controlled porosity osmotic pump (CPOP) tablet for scanning electron microscopy?

In order to assess the shape and size of pores formed by dissolving the pore former in the semipermeable membrane structure, SEM images are needed. Cellulose acetate was used in the coating...

15 February 2021 6,135 3 View

Formulate model for one integer optimization?

I am working on one optimization problem. the model with two states, the transition between the two states based on one threshold value (L = 5, which L< 5 -> Normal state, L== 5 ->...

11 February 2021 4,045 3 View