An intravenous (IV) formulation is desired for a high dose drug that needs to be delivered over a period of 8 to 10 hours. This sustained release approach would allow a bolus of drug (approximately 40 to 60%, burst release ) to be delivered quickly upon IV administration followed by the remaining dose to be delivered in a near zero order fashion.
(tramadol HCl) Extended-Release Tablets
The volume of distribution of tramadol in small dosages, following intravenous dose.
The binding of tramadol to human plasma proteins is approximately 20% and binding also appears to be independent of concentration up to 10 µg/mL. Saturation of plasma protein binding occurs only at concentrations outside the clinically relevant range.
http://www.janssenpharmaceuticalsinc.com/assets/ultramer.pdf
Sustained release nano-particles, like liposomes and niosomes can be prepared for parenteral administration
am looking for suitable technology which can full fill my given criteria. i have tried above mentioned technology. please suggest me modified form of these to fullfill my criteria
Yes Dear
It is possible. Intravenous drug release can be tailored by Temperature Controlled Hydro gels using various Polymers
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