Is there a reliable anoikis biomarker(s)?

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How to increase the efficiency of targeted protein degradation during cancer chemotherapy?

In recent years, various strategies for targeted protein degradation have been developed using the ubiquitin-proteasome system or the autophagy-lysosome system (PROTAC, LYTAC, etc.). However,...

22 September 2023 6,585 0 View

How to target the SARS-CoV-2 coronavirus proteome?

The fight against COVID-19 by targeting individual proteins has serious limitations. How to target a whole coronavirus proteome?

09 June 2020 3,821 3 View

What do you think about increasing the efficiency of targeted protein degradation in cancer?

Various strategies for targeted protein degradation have been developed using the ubiquitin-proteasome system or the autophagy-lysosome system (PROTAC, LYTAC, etc.). However, despite significant...

01 January 1970 2,215 0 View

How to distinguish two programmed cell deaths, anoikis, from necroptosis?

Cell death is programmed and depends on the growth conditions under normal conditions. Cells usually die in different ways, and this can be important when choosing a therapeutic strategy against...

01 January 1970 6,912 2 View

Why not we are following sars COVID 19 guidance?

If the case of Irak is of December 2020 then i think I can suggest pl follow all the infection cause and death, already in our researchgate.

19 July 2024 3,356 2 View

Any tips for cell counting in 96-well plate?

Dear colleagues, I am currently using HCT-116 adherent cells for cell culture in 96-well plates and have some questions regarding cell counting. I have tried various methods and found the most...

22 June 2024 1,124 5 View

3T3-F442A cells not adhering to coverslip?

Hi, I am attempting to culture 3T3-F442A cells and carry out IF staining. I'm testing a variety of different compounds on the cells (e.g. lopinavir, clozapine, olanzapine etc.) Up until recently,...

16 June 2024 2,754 0 View

Can we call N-acyl homoserine lactone (N-AHL), a biomarker for the formation of biofilms?

Is there scientific evidence that proves that the presence of N-acyl homoserine lactone can account for the bacterial biofilm population?..

13 June 2024 3,776 2 View

Any biomarker (cost effective) to detect gastric cancer?

03 June 2024 7,208 3 View

Why am I seeing no color change of the positive control cell death assays?

I am currently running Cell Death ELISAs, using the Roche Cell Death Detection ELISA kit. My samples are from the supernatant of bacterially infected primary canine cells. I am seeing no color...

02 June 2024 8,682 1 View

What impact will Ebrahim Raisi’s death have on Iran’s domestic and foreign policies? Are there any potential security implications following hs death?

Impact on Iran’s Policies: Domestic: Raisi’s death may lead to shifts in Iran’s political landscape. Foreign Policy: Immediate changes are unlikely, as the supreme leader holds final...

20 May 2024 3,143 3 View

Cell death upon the use of charcoal stripped FBS?

Hi all, I am trying to induce decidualization in primary human uterine fibroblasts. The problem is that when i use charcoal stripped FBS instead of normal FBS, it causes a massive cell death....

16 May 2024 6,990 3 View

Apart from basic bone remodeling markers, which other blood biomarkers do you think have potential to predict fractures in older adults?

Currently, there are numerous blood biomarkers that have been linked to fractures and increased fracture risk (for example, IL-6). Considering the current evidence, which ones do you think are the...

10 May 2024 6,097 2 View

Is HK-2 reliable in its expression of kidney injury biomarkers?

I am trying to establish a model of hypoxia-reoxygenation in HK-2 cells in order to determine their expression of kidney injury biomarkers (e.g. KIM-1, NGAL, etc.) via qPCR. However, I am finding...

09 May 2024 9,223 0 View