In some patients using the antihypertensive "Co-tareg 160/12.5" and "Isoptin 240 retard" as a co-drug, they complain of chronic fatigue and perhaps minor stiffness in some skeletal muscle, particularly the neck and shoulder muscles.
Yes, it has been reported. Parkinsonism is a frequent side effect of some calcium channel blockers (CCB), especially cinnarizine and flunarizine. CCB-induced parkinsonism (CCBIP) usually improves spontaneously after discontinuation of the offending drug, but many patients exhibit persistent symptoms.
See also:
Calcium channel blocker-induced parkinsonism: clinical features and
comparisons with Parkinson’s disease
Pedro J. Garcı´a-Ruiza, Feelix Javier Jimenez-Jimenezb,*, Justo Garcı´a de Ye´benesa.
But L-type calcium channel blockers of the dihydropyridine class may have potentially neuroprotective effect and protect again Parkinson's disease - "L-Type Calcium Channel blockers and Parkinson’s Disease in Denmark"
Beate Ritz, MD, PhD,1,* Shannon L. Rhodes, PhD,1 Lei Qian, PhD,2 Eva Schernhammer, MD, DrPH,3 Jorgen Olsen, MD,4 and Soren Friis, MD4
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917467/
Good question. As Luiza_Chwiszczuk already commented some calcium channel blocker have antidopaminergics properties and may induce extrapyramidal reaction including dystonia (Micheli F et al. Flunarizine- and cinnarizine-induced extrapyramidal reactions Neurology. 1987 ;37(5):881-4). Certainly this is not frequent at all with dihydropyridine, but there are anecdotic cases
In any cases, some patients with mild dystonia complain of ¨stiffness¨ …so dystonia might explain this peculiar side effect
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