Several studies indicated urine flow and Bowman's capsular space were increased/dilated in diabetic nephropathy. Is it possible that the Bowman's capsular space declined in severe diabetic nephopathy (because mesangiolysis, tuft-capsule adhesion or hyalinosis) while urine flow remains high?
There is no cause effect relationship between urine flow and bowman space volume.Urine flow increases due to osmotic duresis. Bowman space may be dilated due to initial hyperfiltration or later, because of increases in intracapsular pressure due to incomplete proximal water reabsorption due to the glucose overload. Of course in advanced stages adhesions, fibrosis etc may limit Bowman space expansion and diuresis can persist.
I think no cause effect relationship between urine flow and bowman space volume.Bowman space may be dilated due to hyper filtration ,obstruction ,steno sis or ....
I am agree with Mario Barac-Nieto, Urine flow increases due to osmotic diuresis, and normal rate of filtration is 125 ml/min, equivalent to 80 times the daily blood volume. Measuring the glomerular filtration rate (GFR) is a diagnostic test of kidney function so you can correlate the kidney impairment with the GFR
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