There appears to be a low dose therapeutic window for alpha lipoic acid in both schizophrenia and ischemia reperfusion. Could disturbances in glutathione homeostasis, either through increased synthesis or reduced degradation be a factor? The half-life for both alpha lipoic acid and glutathione is very short.
Jutta Eschle
Found this at PubMed:
Nutrients. 2012 Oct; 4(10): 1399–1440.
Published online 2012 Oct 9. doi: 10.3390/nu4101399
PMCID: PMC3497002
Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases
William M. Johnson,1,2 Amy L. Wilson-Delfosse,1 and John. J. Mieyal1,2,*
Perhaps it could be helpful to you?
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Sheila E J Seybolt
Thank you very much for suggesting the article, an interesting read with many promising paths to explore.
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