Can be measure pain by the measuring the amount of Enkephalin in the blood ?
The description of pain for patients and its measurement by practitioners is challenging. When a member is injured, the pain of the affected nerves passes through messages that cause pain.
Neurological messages carry the pain to the spinal cord and then to the brain. Upon arrival of the painful nerve signal to the nerve rope, a pain message Is suppressed by a group of neurotransmitters called "ankophalin". When enkephalins are spinal cord neurons
They come to prevent the transmission of messages to the brain. Drugs have the same functionalities as enoxalones and to protein receptors Pain occurs in the nerve routine and prevent the transmission of pain messages to the brain.
This paper may interest you: Neural Plast. 2017; 2017: 1546125. Published online 2017 Jul 11. doi: 10.1155/2017/1546125PMCID: PMC5525068PMID: 28781901
Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience
Mathilde S. Henry, 1 Louis Gendron, 2 , 3 Marie-Eve Tremblay, 1 , * and Guy Drolet 1
Endorphins are naturally produced in response to pain, but their production can also be triggered by various human activities. Vigorous aerobic exercise can stimulate the release of β-endorphin . It is controversial to measure value in blood.
The concentration of endorphins in the plasma does not reflect the concentration in the brain. As a consequence, the use of the dynamics of the concentration of endorphins in plasma is meaningless to assess the effectiveness of pain treatment.
Wait a minute. I am intrigued by Oshani's question. Bhanu's answer does not a disqualify a blood assessment because endorphins are produced in response to exertion pain, correct? If these endorphins block pain transmission to the brain then levels of endorphin in the brain (a concern of Katsnelson) do not matter, right? Yes, a few assumptions here. If the endorphin levels can be assessed transcutaneously, this would be a neat way to assess pain in children whose pain reports are suspect. Even if the transcutaneous assessment of endorphins is not possible now, it would be an important research goal to give pediatric dentists such as myself a non-invasive, objective means to assess pain in young children who are known to "symptom magnify". Can someone disprove my assumptions for me please? Nice question Oshani!
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