Just wondering whether topical spinosad would be effective for the control of sarcoptic mange in pet pigs.
Thanks, Dr. Antary. My concern was that spinosad is not effective against all mite species, and I could find nothing about its effectiveness in the treatment of sarcoptic mange in any mammalian species (including humans). I wondered why that was, and thought that maybe Sarcoptes scabiei is one of the mite species against which its effectiveness is limited. Any thoughts?
No, I haven't used it; I was simply looking for information on topical spinosad that is specific to S. scabiei. According to the literature, not all mite species are susceptible to spinosad, which surprised me, as I thought it was a fairly broad-spectrum insecticide and acaricide. I was wondering about S. scabiei, but I haven't been able to find any information on whether this particular mite is susceptible to spinosad.
Dear Christine, I did a small review about use of Spinosad against mites, I found it has a low activity on mites but strong activity against lice. Several Public Health programs in USA, England and South America against mites and lice refers the use of Spinosad against lice but not for mites. More over studies in vitro against different mites shows low activity. On the other hand, it is a expensive product.
Article Comparative in vitro evaluation of contact activity of flura...
https://clinicaltrials.gov/ProvidedDocs/17/NCT02485717/Prot_000.pdf
When admintered oraly is effective against several mites.
https://eprints.ucm.es/29995/1/T36038.pdf
Best regards
Thanks, Dr. Hernandez. I had read that first abstract. I still haven't seen any data (in English - alas, the only language in which I'm fluent :-( on the in vivo use of spinosad for the treatment of sarcoptic mange. I have used spinosad with great effect against fleas, ticks, and lice in dogs and goats, but I've not tried it for mite infestation of any sort.
As for its expense, I used a commercial garden spray product (which comes as a concentrate, to be diluted before use) and simply doubled the concentration recommended for foliar application. It cost mere pennies per dose and it worked a treat!
Thanks so much for your response.
ADDENDUM
I just skimmed the clinical trial doc you mentioned above. For those interested, here is the paragraph citing the rationale for the study:
1.2 Rationale
ParaPRO conducted a proof-of-concept trial that was a double-blinded, two-arm 28-day placebo controlled study of subjects randomly assigned 3:1 to NatrobaTM or Placebo.[4] Subjects applied a single treatment over the entire body from the neck down to the toes (including the soles of the feet) in-clinic on Day 1, rubbing the investigational product (IP) into the skin and waiting 10 minutes before getting dressed. Showering or bathing was to occur no earlier than 6 hours after treatment. Efficacy assessments included visual skin assessment of scabies infestation (visual assessment of burrows, lesion counts, and presence of new lesions), skin scraping for microscopic examination (for evidence of mites) and a pruritus score by a subjective scale. The scabies scores were changed by -1.4 with Natroba (p=0.0020), compared to -1.0 with Placebo (p=0.2500). The count of lesions was significantly decreased with Natroba (-28.1, p=0.0020), however, not with Placebo (-9.8, p=0.6250). Microscopy showed significant improvement, 13/15 negative with Natroba (p=0.0074), compared to 3/5 with Placebo(p=1.000).
Christine,
My pleasure. I have lernead a lot from you.
Best regards.
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