Is there any reference that discussed the hydrolysis R-C=O NH NH CH2-R'?
(The R or R' might be Alkyl, Aryl or heterocyclic)
Dear Ahmed,
the substituted hydrazide group is stable at neutral medium. Of cause if you use extreme alkaline or acidic pH it hydrolyses to carbonic acid and substituted alkyl hydrazide. Article Synthesis of hydrazides of heterocyclic amines and their ant...
Dmitriy Berillo Thank you Dr. Dmitriy for your answer.
Actually, I agree with you that it should be stable in a neutral medium but I am surprised that some molecules can be hydrolysis if you use diluted acid during the work-up. In addition, it can give you the cyclic form (2,5-oxadiazole ) if you use polyphosphoric acid.
Thank you for sharing this information, i will keep it in mind. It is very interesting cyclisation approach, I will check it out.
- Badges
- Science topic
- Similar topics
- Linguistics
- Composition Studies
- Writing