Hi Dr. Das. I am not sure, I understand the question correctly. Where should activity be hapatoprotective at all? I assume we talk about exercise, sports and so on. If activity helps you to prevent to gain weight, and therefore to prevent diabetes, then there is some rationale (yet to my knowledge, not direct proof) that it prevents fatty liver disease. But fatty liver disease it self does also not be a problem join most instances. If fatty liver disease progresses to NASH, then it might become a problem (also at this point, the car that hits you on the road might be the killer knocking on your door first). Exercise and even loose wight to normalise NASH has never been prove to be of any help to the liver. Yet up to 90% of doc's think it helps... (se attached the EASL-GUidlines from 2013). Despite this, activity will probably help as there is better data, that it helps/prevents diabetes and coronary artery disease. Both the far higher risk to die from, then from liver disease even if an established NASH is present.

Regards, Bruno

Article From NAFLD in clinical practice to answers from guidelines

go with prophylactic activity

HI Poppy, in my lab we are doing hepatoprotective activity and up to now we did only prophylactic activity. But smaller number of papers with curative procedures should not discourage you in doing both experiments. A wile ago I thought about curative experiments but never performed them. So if you have funding and chemical that you want to test just perform both.

Thank you all for your suggestions. It really helped me.