This is confirm that L-Methylfolate is a medical food product approved by FDA. This is mainly used for resistant depression as supplement. But can anybody tell me either it is used for pregnancy (MTHFR mutant) who is suffering from recurrent miscarriage? Is this approved by bodies like FDA, e.g Gynecological society of that country?
Dear Dr Hasnat,
After their intake, natural folate and synthetic FA are converted to 5-MTHF. A nature-identical folate of 5-MTHF as 6S-5-MTHF has been synthesized as a calcium salt and marketed as Metafolin. At present, the use of 6S-5-MTHF seems to be better than the use of FA in several aspects: it does not mask B12 deficiency, it’s already a biologically active form, it doesn’t cause unmetabolized FA in blood, and it’s absorbed and utilized at least as well as FA. Although there are no clinical trials on the effectiveness of 5-MTHF in preventing NTDs, metabolic studies have shown that 5-MTHF is a biologically active form of the vitamin and it seems to be at least as effective as FA in improving folate biomarkers. The literature clearly shows that a better food folate intake is associated with better folate markers and that food folate can prevent NTDs (by increasing folate status).
Regarding pregnancy who is suffering from recurrent miscarrige, yes, I recommend Methylfolate.
Аs a small contribution from my side, I am sending you my article:
http://www.omicsonline.org/open-access/folic-acid-supplementation-in-prevention-of-neural-tube-defects-2161-038X-1000e121.php?aid=59819
Dear Dr Emilija Jasovic-Siveska, Thanks for the message and article. The problem is I need a regulatory body approval anywhere in the world which I can use as reference. This is true there is not much clinical trial regarding L-methylfolate.
http://www.medicinesinpregnancy.org/bumps/monographs/USE-OF-METHYLFOLATE-IN-PREGNANCY/
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