The blood–brain barrier is composed of high-density cells restricting passage of substances from the bloodstream much more than do the endothelial cells in capillaries elsewhere in the body. over 95 percent of drugs do not show any useful activity in the brain due to the blood–brain barrier. therefor opening them for a short while can be very effective.
Hi Maryam, if magnetic fields could open the BBB then MRI would have deleterious consequences.
I think the effect of MF depends principally on the dose used. MF: include ELF-MF (Pulsed MF, sinusoidal MF...), Static MF, Radiofrequency...those mentioned, are only the wave form but in here is important take into account also: the time exposure, the intensity, and the frequency of the field...and homogeneity... Every dose used can have a different response depending on the factors mentioned before...Those article above is examples.....
https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-186X(200007)21:5%3C338::AID-BEM2%3E3.0.CO;2-Q
https://onlinelibrary.wiley.com/doi/abs/10.1002/jemt.1070270608
Hi Maryam, if you want to open the BBB to allow drugs to cross it and diffuse in the brain, then ultra-sound and microbubbles. It is used in various preclinical studies and even in human for cancer therapy and now for Alzheimer's disease:
https://www.nature.com/articles/s41467-018-04529-6
Here is what was done in my previous lab for preclinical studies:
Article Fast in vivo imaging of amyloid plaques using μ-MRI Gd-stain...
- Badges
- Science topic
- Similar topics
- Physical Sciences
- Electromagnetics
- Electromagnetic Fields