Direct delivery to tumors remains a problem in most nanoparticle applications because the immune system rapidly removes circulating nanoparticles by ultimately accumulating them in the liver and kidneys. Can nano graphene oxide with enhanced tunable fluorescence be used as bioimaging probes without attaching antibodies?
It may be possible to self image the tumour cells with GO via chemodosimeter technique via selective ion channels in cancer cells. GO assisted chemodosimeter for detection of fluoride ion (carcinogenic) has successfully been developed. For details one may follow the link
http://pubs.acs.org/doi/abs/10.1021/am502142d
Same approach may be utilized for selective detection of ion channels present in cancer cells.
http://webcache.googleusercontent.com/search?q=cache:ONk9VMAm0-kJ:www.alomone.com/upload/newsletters/modulator%252017%2520papers/ion%2520channels%2520in%2520cancer.pdf+&cd=3&hl=en&ct=clnk&gl=in
Many thanks Dr. Varun Saxena for your suggestion. I really appreciate your response. This idea went very well. Best regards
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