Maybe the type of surfactant ( non-ionic, ionic, anionic, Zwitterionics/Amphoterics) can influenced how the successful of formation of Nanostructured Lipid carrier?
Or
Maybe it also can form without the using of surfactant?
Thanks in advance
Dear Farhanim:
Nanostructured lipid carriers (NLC) are produced using blends of solid lipids and liquid lipids (oils). To obtain the blends for the particles matrix, solid lipids are mixed with liquid lipids, preferably in a ratio of 70:30 up to a ratio of 99.9:0.1. Because of the oil presence in these mixtures, a melting point depression compared to the pure solid lipid is observed, but the blends obtained are also solid at room and body temperatures . The overall solid content of NLC could be increased up to 95% .
Müller, R.H., Mäder, K., Lippacher, A., Jenning, V., Solid-liquid (semi-solid) liquid particles and method of producing highly concentrated lipid particle dispersions, in PCT/EP00/04565. 2000.
Regards.
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