Is the mesylation of both hydroxyl groups and then selective amination of one hydroxyl end followed by cyclization on another end via SN2 displacement? If you have any idea, please comment on this.
Dear,
In theory, this is feasable. However several things should be kept in mind. First, as the end groups are located relatively far from each other (depending on the PEO MW), the speed and the yield of the reaction might be low. Secondly the reaction might (depending on your chemistry) also occur intermolecularly in this way developing PEO with a higher MW than theoriginal one.
The selectivity of the reactions you mention is rather low (from personal experience).
I sincerely hope this helps you further.
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