In my humble opinion, I feel that it is difficult to combat the thermal decomposition of the analyte that you are wishing to analyze using GC-MS. An alternative would be to study the degradation products of your analyte and if you are still planning to use GC-MS then try to opt for a softer ionization to increase the abundance.

I have also found a reference spectrum with the instrumental specifications. Please go through these documents, I hope it helps:

https://mona.fiehnlab.ucdavis.edu/spectra/display/JP005415

Article Thermal degradation of aqueous 2-aminoethylethanolamine in C...

Mr. Hwang,

Your analyte shows a tridentate capability of binding metal ions or NH4+-ion. Thus, depending on experimental conditions (presence of salts of transition metal ions or alkali metal ions; or even only depending on the pH,) there can be achieved significant ionization efficiency without chemical substitution.

Toward, determination of your analytes in exact quantitative terms, please, consider the content of the following discussion. In particular, please, focus your attention on the reference section, dealing with our innovative own-authored (mine and my co-author's one) theory and model formulas for exact (or absolute) quantification of analytes by mass spectrometry, showing coefficients of linear correlations between our formulas and the experiment /r/ = 0.99997 - 1.

[https://www.researchgate.net/post/How_to_extract_and_purify_disaccharide_peptides_and_lactoyl_peptides_from_Mycobacteria_cell_wall]

Currently, our approach to treat quantitative the experimental mass spectrometric variables appears the most accurate, precise, selective, sensitive and universally applicable to different MS ionization methods, experimental conditions and type of analytes, method among all known quantitative methods.

Given that there are published GC retention indices for the compound, it is possible to determine the compound using GCMS. That being said, being polydentate, it is likely that there will be issues with the material bonding to small active sites within the analysis system. Thermal degradation as mentioned above may also be problematic.

There are a variety of derivatizing agents for amines that make GC separation and analysis significantly more reliable by decreasing the polar interactions of the amines. If you really need the sensitivity and selectivity of GCMS for the measurement of this compound, then derivatization will improve your chances of making reliable measurements. This assumes that you properly verify and validate the derivatization process addressing all of the feasible matrix effects in the derivatization reactions.

Derivatization will add mass to the derivatized analyte, which will aide in getting ions that are going to be further out of the low mass range where the background is usually noisy. This may be a consideration depending upon the quantity of the compound that you need to measure.

Chemical Ionization GC-MS used to be commonly used for problems like this. Methane CI specifically, for "softer" ionization that does not overenergise and destroy the object analyte.

In general, GCMS (with EI type ionisation mode) analysis of these type compounds is not difficult when the sample investigated is analyzed as trimethylsilyl derivatives (by derivatisation of the sample with using BSA reagent). In their mass spectra the peaks of the fragment ions [M - CH3]+ and [M]+ are observed as the most characteristic peaks.

Please look at the following below links which may help you in your analysis:

https://gcms.cz/labrulez-bucket-strapi-h3hsga3/A01584_7f86e91ac7/A01584.pdf

https://www.osha.gov/dts/sltc/methods/partial/pv2116/pv2116.html

https://core.ac.uk/download/pdf/81904923.pdf

Thanks

Mr. Hwang,

Regarding method PV2116, provided by the United States Department of Labor and shown in the posting by Mr. Elgailani as link [ https://www.osha.gov/dts/sltc/methods/partial/pv2116/pv2116.html], I should emphasize that the recovery is low (92.7 %.) Please consider the data on Figure 1.2.1. The major reason for this value is the fact that there has been used UV-detection of the analytes. In this context, please consider some chemometric data on optical spectroscopic methods for quantification shown as references [2*-4*] in discussion [A] shown below.

[A] [https://www.researchgate.net/post/Sensitivity_Coefficient_in_Uncertainty_Calculations_for_HPLC_assay_method_UV_assay_methods_and_pH_measurement]

Conversely, our innovative mass spectrometric method for quantification of analytes in solution provides absolute method performances in chemometric terms as shown in my previous posting to your question.

Eui-Tak Hwang , so as you see Isam Eldin Hussein Elgailani posted useful links.

THus, you can do it. IF there is a risk of thermal decomposition, think about cold on-column injection.

best regards,

GB

Actually, it is a critical task, however you may visit the following link, I think it will be helpful for you:

https://core.ac.uk/download/pdf/81904923.pdf