We are planning to do BT474 xenografts in Nude mice. Though most of the article mentioned of using E2 for BT474 xenografts, I came across some other article in which the use of E2 was not mentioned.
My question is, if it is required to use E2 implant to develop BT474 tumour in nude mice?
Matt Brown
I believe estradiol pellets are good for the growth of BT474 tumors. Realistically the tumors will form (see http://altogenlabs.com/xenograft-models/breast-cancer-xenograft/bt474-xenograft-model/) but adding the E2 pellet boosts the overall progression of the tumor. Make sure to check for the growth curves and how they are affected by various compounds, and then that should inform how you run your own studies.
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