Sure !! great idea !

It is depending on prodrug property. Usually, the transdermal route is chosen for avoiding 1-st pass metabolism of drug in the liver. If that prodrug has extreme problem from oral route and has suitable property for transdermal delivery, it may be good idea to deliver this prodrug via transdermal route.

Thanks Claudi Nastruzzi and Ekapol Limpongsa.

I am planning to prepare a transdermal delivery of an anticancer prodrug for the breast cancer. The hypothesis is that the TD system will be applied on the breast skin and the drug will get permeated through the skin and will have effect on the brease tumor.

In this case will it be Okay?

If this prodrug can permeate through skin and deposit at the cancer,

- it may not work as anticancer because it's PRODRUG. It has to transport to the liver to be converted to active metabolite. OR

- it may work, if this prodrug has enough activity or or if enough part of prodrug can be converted into active form in this administration area.

You should check it's activity and conversion of it in this area.

Thanks Ekapol Limpongsa.

You should think of the metabolizing enzymes in the skin and the possibility that your prodrug can be broken to the active moiety and give action at the target site.

Dear Ossama Mohamed Sayed,

Thank you. I will check if the enzymes metabolizing this drug are present in skin or not.

Dear Ali Abdil Razzaq Muhammed Noori Aldallal,

Thank you very much for your very useful and elaborative answer. It will surely add value in my research. an Thanks for the articles.

Agree with Ali but indeed the idea is wonderful, applying such drugs through transdermal rout.  .

What is the mechanism of breakdown?

Does the prodrug breakdown to toxin inside the cancer cell?

I think answer will largely depend on that