I too agree that action will be facilitated. Bt how long its action lasts for, I mean does it get absorbed very rapidly in vitrectomized eye as there won't be any depot formation of IVTA? Secondly can rapid absorption increase the risk of IOP rise? And, does it coat the residual cortical vitreous or retina, and obscure the vision for a period of 1-2 week?
Тriamcinolone acts up to 1mo . In my opinion it will be no difference in IOP rise in Vitrectomised or nonoperated eye, and the drug will not obscure the vision if no sterile enophthalmitis, to prevent it use the drug without conservant
Intravitreal drugs are cleared very rapidly after vitrectomy; the same is true for triamcinolone. Its intravitreal half-life is halved and rate of clearance increased by 50% in a vitrectomized eye (Retina. 2005 Jul-Aug;25:556-60). In spite of faster clearance, it remains a valid choice for pharmacotherapy in these eyes for diabetic as well as other types of macular edema (Eur J Ophthalmol. 2016 Mar 7:0. doi: 10.5301/ejo.5000768); much better than anti-VEGF drugs which suffer much more rapid clearance post-vitrectomy. Finally Ozurdex (dexamethasone depot) is probably a better choice than triamcinolone in post-vitrectomy eyes in terms of durability (J Ocul Pharmacol Ther. 2014 Nov;30:709-16), though a recent head-to-head comparison between triamcinolone and Ozurdex found them comparable in efficacy in ERM surgery(Ophthalmic Surg Lasers Imaging Retina. 2016 Mar 1;47:232-7). My own experience over two decades confirms the usefulness of post-vitrectomy steroid depots; and also, lesser chances of secondary glaucoma.