Trying to see the role calcium ion channels may play in rare causes of sexual dysfunction. When people are suffering from hyperparathyroidism their symptoms are thought to be caused by calcium channel overload. Is this also the same reason for the sexual symptoms? Developing research for the role of Calcium Channels and Post SSRI Sexual Dysfunction Syndrome (PSSD).
Pharmacol Biochem Behav. 2014 Jun;121:88-101. doi: 10.1016/j.pbb.2013.10.004. Epub 2013 Oct 12.
Sexual side effects of serotonergic antidepressants: mediated by inhibition of serotonin on central dopamine release?
Bijlsma EY1, Chan JS1, Olivier B1, Veening JG2, Millan MJ3, Waldinger MD1, Oosting RS1.
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Abstract
Antidepressant-induced sexual dysfunction adversely affects the quality of life of antidepressant users and reduces compliance with treatment. Animal models provide an instructive approach for examining potential sexual side effects of novel drugs. This review discusses the stability and reproducibility of our standardized test procedure that assesses the acute, subchronic and chronic effects of psychoactive compounds in a 30 minute mating test. In addition, we present an overview of the effects of several different (putative) antidepressants on male rat sexual behavior, as tested in our standardized test procedure. By comparing the effects of these mechanistically distinct antidepressants (paroxetine, venlafaxine, bupropion, buspirone, DOV 216,303 and S32006), this review discusses the putative mechanism underlying sexual side effects of antidepressants and their normalization. This review shows that sexual behavior is mainly inhibited by antidepressants that increase serotonin neurotransmission via blockade of serotonin transporters, while those that mainly increase the levels of dopamine and noradrenaline are devoid of sexual side effects. Those sexual disturbances cannot be normalized by simultaneously increasing noradrenaline neurotransmission, but are normalized by increasing both noradrenaline and dopamine neurotransmission. Therefore, it is hypothesized that the sexual side effects of selective serotonin reuptakeinhibitors may be mediated by their inhibitory effects on dopamine signaling in sex brain circuits. Clinical development of novel antidepressants should therefore focus on compounds that simultaneously increase both serotonin and dopamine signaling.
© 2013 Elsevier Inc. All rights reserved.
KEYWORDS:
Animal model; Antidepressants; Drug-induced; Ejaculation; Sexual behavior; Sexual dysfunction
Dr. Tuzan, thank you so much for taking time to help answer my question. The answer you provided applies to "SSRI induced sexual dysfunction", the condition to which my team is attempting to treat is "Post SSRI Sexual Dysfunction"; two separate conditions. POST SSRI Sexual Dysfunction pertains to permanent sexual side effects from the previous use of SSRIS that cause Penile/Clitoral Anesthesia, erectile dysfunction,anorgasmia, absent ejaculation, Absent Libido, and in most cases causes severe cognitive/memory impairment.
The condition known as hyperparathyroidism causes sexual dysfunction, cognitive/memory impairment, and lack of motivation. My question is, does Hyperparathyroidism cause these effects as a result of calcium ion channel overload????
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