In cancer, the most awful situation after getting a chemotherapeutic agent, is its delivery. I heard about various vectors employed in their delivery. But is there any clinical or associated reports regarding to this concern?
There are many types of carriers used for chemo delivery in cancer cells like:
1. Dendrimers and nanoparticles
2. Polymers
3 ADC
4. Ligant conjugation (transferin for example)
5 Liposomes
6. Dyclodextrones
But all of them they cave many pros and equal cons in ADMET
You need also to consider that in cancer you have to deal with heterogeneity and you may need bystander phenomena to happend.
I. Papasotiriou
Have you ever thought about WGA (wheat germ agglutinin, that's a lectin present in grains of grass)? That's a small molecule that binds very effectively to acetylglucosamine and N-acetylneuramine acid. It is used to "transport" different substances into the cells . It also passes the bood-brain barrier.
Toxicol Appl Pharmacol. 2011 Feb 15;251(1):79-84.
Vaccine. 2011 Oct 13;29(44):7631-7.
J Pharm Sci. 2013 Apr;102(4):1281-9.
Int J Pharm. 2010 Nov 15;400(1-2):201-10.
Pharm Res. 2012 Feb;29(2):546-58.
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