In a typical moderation model with one moderator, is it a problem if the moderator and the dependent variable show a strong correlation (say 0.85)? What if a strong correlation exists between the moderator and independent (predictor) variable?

Another related question to moderation is that: Why sometimes when we switch the dependent and independent variables in a moderation model with the same moderator variable, the significance of the moderation changes? For example, when a model with say rumination as the independent variable, depression as the dependent variable, and gender as the moderator variable is significant; why it become non-significant when we switch the location of dependent and independent variables, put depression as independent and rumination as dependent (the example is not real, just to convey the pint).

Please let me know if any further information is required to make it clearer. Thanks in advance for your help :)

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