I am confused if 2-hydroxypropyl-β -cyclodextrin is a crosslinking of 2-hydroxypropyl and β -cyclodextrin. I have seen modifications of β-cyclodextrin with various cationic and anionic branches, is 2-hydroxypropyl -β -cyclodextrin similar to crosslinking?
The 2-hydroxypropyl groups are connected to the beta-cyclodextrin skeleton by an ether linkage as shown in the attached file. There is no cross-linking there.
(2-hydroxy)propyl, and the dominant substitution occur on the secondary oxygens.
Please note that HP-cyclodextrin (HP-CD) is prepared by the reaction of CD with propylene oxide (PO). PO can react both with OH-groups of the glucose monomers in CD and with OH-groups of already attached HP-substituents. See the attachment in my earlier comment. This may give rise to complex substitution patterns. The analysis of such patterns is described in C. Yuan, B. Liu, H. Liu, Carbohydrate Polymers 118 (2015) 36-40. You can also look in Google Scholar for substitution patterns in HP-starch and/or HP-cellulose, as basically the same analytical methods are applied.
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