In Avian Bursa, Spleen and bone marrow samples which will exhibit higher expression of Interleukin 6 (IL-6) provided that the individual from whom the samples were taken had been infected by a virus?
Are there any rules of thumb to follow or well understood principles that would indicate which tissue sample would contain 'more' IL-6
Some rather speedy responses would be much appreciated.
May Thanks!
IL-6 is produced primarily by T lymphocytes and macrophages so any tissue with these cells could produce an IL-6 response. The chicken spleen clearly will. The bursa is harder to say as it tends to be associated with B lymphocytes and shrinks as the bird ages. Bone marrow will depend more on the infection. We have measure IL-6 expression in gut, spleen and liver in a number of bacterial infections of the chicken-the methods are well established and I am sure there is data in the vast avian virology field which may answer the bursa question
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology