If dead cells of microorganisms forming a biofilm on a stent, accumulate due to actions of antimicrobials, could they provoke inflamation?
Yes
It could induce infections for 2 reasons.Very few cells could escaped the effect of antimicrobials and may cause inflamation.Also autolysed molecules of cell could induce prostaglandin local secretion which in turn leads to inflamation .It needs a study
The Biofilm itself protects the bacteria from antimicrobials. The bacteria involved in biofilm are not dead. Moreover bacteria produce lipopolysaccharide when involved in biofilm formation. The produced LPS (also other Extra polymeric substances (EPS) still remain active even if the bacteria is dead. The LPS produced by the bacteria does induce inflammation.
I think you are asking whether these cells could provoke inflammation and the authors precisely missed the point and tried to explain infection. Well, let me ask you whether you have observed that a sterile needle of an injection system can also provoke inflammation inspite of taking all precaution regarding disinfection. Just like this, dead or live bacterial cells are foreign to the body and hence it is the inherent duty of the immune system to get rid of them and one of the method is by inflammation.
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